Pulmonary & Critical Care Fellowship Program
MGH BIDMC Harvard Medical School

Benjamin Medoff

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Benjamin Medoff, MD

Division Chief

Associate Professor of Medicine

 

 

 

Academic Interests

The focus of my research has been on the mechanisms of lung inflammation in the pathophysiology of several important pulmonary diseases, including asthma, lung transplant reject ion, COPD, and idiopathic pulmonary fibrosis. Specifically, we investigate the role of immunity in these diseases including the initiation and termination of inflammation in the lung. My laboratory utilizes animal models of disease, basic immunology and molecular biology techniques, and translational human studies to investigate properties of the immune response in the lung. This includes extensive experience in research bronchoscopy (with over 150 procedures performed), human translational research, and research in epithelial cell biology. The laboratory is part of the Center for Immunology and Inflammatory Diseases, a scientifically diverse and collaborative environment for the study of immune mechanisms of disease and the MGH Fibrosis Center, a multi-disciplinary center focused on mechanisms and treatment of organ fibrosis.

Awards and Recognition

1995     Distinguished Asthma Scholarship

2000     GlaxoWellcome Pulmonary Fellowship Award

2006     American Thoracic Society Unrestricted Research Award

 

A full list of my published work can be found on My Bibliography.

More information can be found on my Harvard Catalyst profile.

 

+Current Projects

  • Epithelial cell to immune cell Notch signaling in asthma
  • Role of CARMA3 in lung inflammation
  • Role of Tim3 on T cells in influenza infection
  • Role of ROCK in pulmonary fibrosis
  • Mechanisms that lead to COPD in HIV infection

+Selected Publications

  • Medoff BD, Sauty A, Tager AM, Maclean JA, Smith RN, Mathew A, Dufour JH, Luster AD. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol. 2002; 168(10):5278-86.
  • Tager AM, Bromley SK, Medoff BD_, Islam SA, Bercury SD, Friedrich EB, Carafone AD, Gerszten RE, Luster AD. Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Nat Immunol. 2003; 4(10):982-90._second author publication.
  • Medoff BD, Seung E, Wain JC, Means TK, Campanella GS, Islam SA, Thomas SY, Ginns LC, Grabie N, Lichtman AH, Tager AM, Luster AD. BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation. J Exp Med. 2005; 202(1):97-110.
  • Medoff BD, Tager AM, Jackobek R, Means TK, Wang L, Luster AD. Antibody-Antigen Interaction in the Airway Drives Early Granulocyte Recruitment Through BLT1. Am J Physiol Lung Cell Mol Physiol.2006; 290(1): L170-8.
  • Medoff BD, Wain JC, Seung E, Jackobek R, Means TK, Ginns LC, Farber JM, Luster AD. CXCR3 and its Ligands in a Murine Model of Obliterative Bronchiolitis: Regulation and Function. J Immunol. 2006; 176(11): 7087-7095.
  • Medoff BD, Seed B, Jackobek R, Zora J, Yany Y, Luster AD, Xavier R. CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma. J Immunol. 2006; 176(12): 7272-7277.
  • Zhou D, Medoff BD, Chen L, Li L, Zhang X, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Nat Acad Sci. 2008, 105: 20321-20326.
  • Medoff BD, Landry AL, Wittbold KA, Sandall BP, Derby MC, Cao Z, Adams JC, Xavier RJ. CARMA3 Mediates Lysophosphatidic Acid Stimulated Cytokine Secretion by Bronchial Epithelial Cells. Am J Respir Cell Mol Biol. 2009 40(3):286-94.
  • Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD. CD11b+ Myeloid Cells are the Key Mediators of Th2 Cell Homing into the Airway in Allergic Inflammation. J Immunol 2009, 182: 632-635.
  • Medoff BD, Sandall BJ, Landry A, Nagahama K, Mizoguchi A, Luster AD, Xavier RJ. Differential Requirement for CARMA1 in Agonist-Selected T Cell Development. Eur J Immunol. 2009, 39: 78-84. PMID: 19130560.
  • Medoff BD, Okamoto Y, Leyton P, Weng M, Sandall BP, Raher MJ, Kihara S, Bloch KD, Libby P, Luster AD. Adiponectin-deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling. Am J Respir Cell Mol Biol. 2009 41(4):397-406.
  • Weng M, Raher MJ, Leyton P, Combs TP, Scherer PE, Bloch KD, Medoff BD. Adiponectin Decreases Pulmonary Arterial Remodeling in Mouse Models of Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2011 Aug;45(2):340-7. PMID: 21075862.
  • Seung E, Cho JL, Sparwasser T, Medoff BD, Luster AD. Inhibiting CXCR3-dependent CD8+ T-cell trafficking enhances tolerance induction in a mouse model of lung rejection. J Immunol 2011 Jun 15;186(12):6830-8. PMID: 21555535.
  • Harris RS, Venegas JG, Wongviriyawong C, Winkler T, Kone M, Musch G, Vidal Melo MF, de Prost N, Hamilos DL, Afshar R, Cho JL, Luster AD, Medoff BD. 18FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma. J Nucl Med 2011, (11):1713-20. PMID: 21990575.
  • Ramadas RA, Roche MI, Moon JJ, Ludwig T, Xavier RJ, Medoff BD. CARMA1 is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma. J Immunol. 2011, 187(12):6197-207. PMID: 22075698.
  • Cho JL, Roche MI, Sandall B, Brass AL, Seed B, Xavier RJ, Medoff BD. Enhanced Tim3 Activity Improves Survival After Influenza Infection. J Immunol. 2012 189(6):2879-89. PMID:22875804.
  • Purushothama Rao T, Mou H, Pardo-Saganta A, Zhao R, Prabhu M, Law BM, Vinarsky V, Cho JL, Breton S, Sahay A, Medoff BD, Rajagopal J. Dedifferentiation of committed luminal epithelial cells into functional stem cells in vivo. Nature 2013. 518: 218-223. PMID 24196716. Editorial in Cell.
  • Causton B, Ramadas RA, Cho JL, Jones K, Pardo-Saganta A, Rajagopal J, Xavier RJ, Medoff BD. CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation. J Immunol. 2015 Jul 15;195(2):683-94. PMID: 26041536.
  • Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD_, Luster AD (_co-last author publication). Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Sci Transl Med. 2016 Oct 5;8(359):359ra132. PMID: 27708065.
  • Knipe RS, Probst CK, Lagares D, Franklin A, Spinney JJ, Brazee PL, Grasberger P, Zhang L, Black KE, Sakai N, Shea BS, Liao JK, Medoff BD, Tager AM. The Rho Kinase Isoforms ROCK1 and ROCK2 Each Contribute to the Development of Experimental Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 Epub ahead of print. PMID: 29211497.
  • Cho JL, Medoff BD. Lung T Cells in HIV Infection: Driven to Exhaustion? 2015 Am J Respir Crit Care Med 191(4): 370-371. PMID: 25679103.
  • Medoff BD, Thomas SY, Luster AD. T cell trafficking in allergic asthma: The ins and outs. Annual Rev. Immunol. 2008, 26: 205-32.