Pulmonary & Critical Care Fellowship Program
MGH BIDMC Harvard Medical School

Elias Baedorf Kassis, MD


Elias Baedorf Kassis, MD

Instructor in Medicine

Areas of Expertise: Investigation and Academic Clinical Medicine

Academic Interests

Mechanisms of lung injury in ARDS, Respiratory physiology and pathophysiology, Patient-ventilator interaction and dyssynchrony, optimization of weaning from mechanical ventilation

A full list of Dr. Kassis’ published work can be found on My Bibliography.

More information can be found on Dr. Kassis’ Harvard Catalyst Profile.

+Current Projects

Prospective studies:
  • Adaptive Support Ventilation in ARDS (PI): a study comparing a new mode of ventilation where parameters are automatically adjusted by the vent to minimize mechanical work and driving pressure, with standard control mode ventilation
  • Pressure-Volume Loops in Respiratory Failure (PI): Investigating the clinical application of pressure-volume loops for PEEP optimization, determination of recruitability, and ventilator optimization
  • Dyssynchrony frequency and clinical correlations (PI): investigation of patients with moderate-severe ARDS and the frequency of specific subtypes of dyssynchrony, and investigating the correlations with sedation, ventilator mode, clinical parameters and patient outcomes.
  • Automation of a novel breathing pattern identification strategy using machine learning for clinical care and research.
  • FAST Study (PI): investigation comparing strategies of SBT frequency and method in order to expedite weaning and extubation
  • Campbell Diagram titration of neuromuscular blockade and sedation(PI): an investigation comparing train of four and Campbell diagram for assessment of adequate paralysis. This will serve as the foundation for a sedation based study using the same method to determine who needs increased sedation and/or paralysis.
  • Intellivent Ventilation (PI): investigation of a new mode of mechanical ventilation that uses ETCO2 to adjust minute ventilation needs and provides support via ASV.
Retrospective Studies:
  • Dyssynchrony pattern phenotypes with clinical correlations and inflammatory markers in EPVent2
  • Looking at PEEP responders or “recruitable” patients in relation to outcomes and response to treatment using recruitment maneuvers and changes in driving pressure in EPVent2
  • Transpulmonary pressure, minute stress, mechanical power in relation to mortality and clinical outcomes in the EPVent2 study
  • How to transition off of lung protective ventilation safely. Using a large retrospective database to model decisions on when and how patients are transitioned safely.
  • Dosing of neuromuscular blockade using train of four modeling dose changes with treatment response
  • Comparison of pre and post Campbell diagram neuromuscular blockade protocol in the ICU

+Selected Publications

  1. Shirali, A. C., Look, M., Du, W., Kassis, E., Stout-Delgado, H. W., Fahmy, T. M. and Goldstein, D. R. (2011), Nanoparticle Delivery of Mycophenolic Acid Upregulates PD-L1 on Dendritic Cells to Prolong Murine Allograft Survival. American Journal of Transplantation, 11: 2582-2592
  2. Baedorf Kassis, E., Loring, S., Talmor, D. (2016), Mortality and Pulmonary Mechanics in Relation to Respiratory System and Transpulmonary Driving Pressures in ARDS. Intensive Care Medicine, 42: 1206-1213
  3. Baedorf Kassis E, Loring SH, Talmor D . (2016) Is transpulmonary pressure-guided PEEP titration really optimal? Response to Yamaga et al. Intensive Care Med. 2016 Nov;42(11):1847-1848.
  4. Baedorf Kassis E, Loring SH, Talmor D. (2017) Recruitment maneuvers: using transpulmonary pressure to help Goldilocks. Intensive Care Med. 2017 Aug;43(8):1162-1163.
  5. Baedorf Kassis E, Loring SH, Talmor D, Terragni P, Mascia L, Ranieri VM. (2017) A fixed correction of absolute transpulmonary pressure may not be ideal for clinical use: Discussion on "Accuracy of esophageal pressure to assess transpulmonary pressure during mechanical ventilation". Intensive Care Med. 2017 May 15. [Epub ahead of print]
  6. Baedorf Kassis E, Loring SH, Talmor D. (2018) Esophageal pressure: research or clinical tool? Medizinische Klinik - Intensivmedizin und Notfallmedizin; "New insights in mechanical ventilation" 2018 Feb;113(Suppl 1):13-20
  7. Baedorf Kassis E, Loring SH, Talmor D. (2018) Should We Titrate PEEP Based on End-Expiratory Transpulmonary Pressure? YES. Annals of Translational Medicine.
  8. Baedorf Kassis E, Loring SH, Talmor D. (2018) Lung Volumes and Transpulmonary Pressure are Decreased with Expiratory Effort and Restored with Passive Breathing in ARDS: A Reapplication of the Traditional Campbell Diagram. Intensive Care Med. 2018 Mar 7. doi: 10.1007/s00134-018-5105-0. [Epub ahead of print]
  9. Baedorf Kassis E, Train S, MacNeil B, Loring S, Talmor D. (2018) Monitoring of Neuromuscular Blockade: A Comparison of Train-Of-Four and the Campbell Diagram. Intensive Care Med. 2018 Dec;44(12):2305-2306.
  10. Su H, Loring SH, Talmor D, Baedorf Kassis, E. (2019) Reverse triggering with breath stacking during mechanical ventilation results in large tidal volumes and transpulmonary pressure swings. Intensive Care Med. 2019 Mar 28. doi: 10.1007/s00134-019-05608-y.