Pulmonary & Critical Care Fellowship Program
MGH BIDMC Harvard Medical School

Jason Griffith

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Jason Griffith, MD, PhD

Instructor in Medicine

 

 

 

 

 

Academic Interests

The overall goal of my research is to understand how immune dysregulation contributes to lung disease. Specifically, we use mouse models of influenza, ARDS and asthma to study how regulatory T cells (Tregs) and trafficking molecules called chemokines regulate the immune response to infection and injury in the lung. Our laboratory is affiliated with affiliated with the Division of Pulmonary and Critical Care Medicine and the Center for Immunology and Inflammatory Diseases at MGH.

Awards and Recognition

  • Parker B Francis Fellowship 2016

  • American Lung Association Biomedical Research Grant awardee 2017

  • NIH K award 2017

A full list of Dr. Griffith's published work can be found on My Bibliography.

More information can be found on Dr. Griffith's Harvard Catalyst Profile.

+Current Projects

  • The role of Treg cell subsets in modulating the immune response to influenza
  • Chemokine mediated positioning of Treg cells in the lung
  • Tissue Treg cells in allergic airway disease
  • Understanding the role of Chemokine Receptor Signaling in memory responses in the lung

+Selected Publications

  • Herbig U, Griffith JW, Fanning E. Mutation of cyclin/cdk phosphorylation sites in HsCdc6 disrupts a late step in initiation of DNA replication in human cells. Mol Biol Cell. 2000 Dec;11(12):4117-30.
  • Gratton JP, Yu J, Griffith JW, Babbit RW, Scotland RS, Hickey R, Giordano FJ, Sessa WC. Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo. Nat Med. 2003 Mar;9(3):357-62.
  • McDevitt MC, Xie J, Shanmugasundaram G, Griffith J, Liu A, McDonald C, Thuma P, Gordeuk VR, Metz CN, Mitchell R, Keefer J, David J, Leng L, Bucala R. A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J Exp Med. 2006 May 15;203(5):1185-96.
  • Liang J, Jiang D, Griffith J, Yu S, Fan J, Zhao X, Bucala R, Noble PW. CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages. J Immunol. 2007 Feb 15;178(4):2469-75.
  • Griffith JW, O’Connor C, Bernard K, Town T, Goldstein D, Bucala R. Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host. J Infect Dis. 2007 Nov 15;196(10):1553-64. Kamir D, Zierow S, Leng L, Cho Y, Diaz Y, Griffith J, McDonald C, Merk M, Mitchell RA, Trent J, Chen Y, Kwong YK, Xiong H, Vermeire J, Cappello M, McMahon-Pratt D, Walker J, Bernhagen J, Lolis E, Bucala R. A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses. J Immunol. 2008 Jun 15;180(12):8250-61.
  • Kuo P, Abu-Alfa A, Bucala R, Griffith J, Carlson K, Girardi M, Weinreb J, Cowper S. MRI in the era of nephrogenic systemic fibrosis: Review, controversies and suggestions for risk reduction. Applied Radiology. 2009 Apr; 38 (4).
  • Griffith JW, Sun T, McIntosh M, Bucala R. Pure hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. J Immunol. 2009 Oct 15; 183(8): 5208-20.
  • Sun T, Holowka T, Song Y, Zierow S, Leng L, Chen Y, Xiong H, Griffith J, Nouraie M, Thuma PE, Lolis E, Janse CJ, Gordeuk VR, Augustinj K, Bucala R. A plasmodium-encoded cytokine suppresses T-cell immunity during malaria. Proc Natl Acad Sci. 2012 Jul 31; 109 (31) E2117-26.
  • Griffith JW, Luster A. Targeting cells in motion: migrating towards improved therapies. Eur J Immunol. 2013 Jun 43 (6); 1430-5.
  • Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cell for host defense and immunity. Annu Rev Immunol. 2014; 32: 659-702.
  • Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK. The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nat Immuno 2015. 16(5): 495-504. PMCID: PMC4406861.
  • Cho J.L., Ling M.F., Adams D.C., Faustino L., Islam S.A., Afshar R., Griffith J.W., Harris R.S., Ng A., Radicioni G., Ford A.A., Han A.K., Xavier R., Kwok W.W., Boucher R., Moon J.J., Hamilos D.L., Kesimer M., Suter M.J., Medoff B.D., Luster A.D. (2016). Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Sci Transl Med. Oct 5;8(359):359ra132. PMID: 27708065.
  • Adams D.C., Hariri L.P., Miller A.J., Wang Y., Cho J.L., Villiger M., Holz J.A., Szabari M.V., Hamilos D.L., Scott Harris R., Griffith J.W., Bouma B.E., Luster A.D., Medoff B.D., Suter M.J. (2016). Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo. Sci Transl Med. Oct 5;8(359):359ra131. PMID: 27708064.