Pulmonary & Critical Care Fellowship Program
MGH BIDMC Harvard Medical School

Michael W. Donnino, MD

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Michael Donnino, MD

Associate Professor of Emergency Medicine and Medicine

Academic Interests
Dr. Donnino is the Founder and Director of the Center for Resuscitation Science (CRS), Vice Chair of Resuscitation Science for the Beth Israel Deaconess Medical Center Emergency Department, and Director of Faculty Research Development.  He is an Associate Professor of Emergency Medicine and Medicine at Harvard Medical School. Dr. Donnino is author of over 160 manuscripts including many in high impact journals such as the NEJM, JAMA, the British Medical Journal, and Circulation. His expertise spans the range of translational research with a particular expertise in clinical trials. He is currently leading or mentoring approximately 8 clinical trials including a 13-center trial on a metabolic intervention in septic shock. On an international level as he is the Vice-Chair of the Advanced Cardiac Life Support Committee for the International Liaison Committee on Resuscitation (ILCOR) – the international committee that sets consensus on science for cardiac arrest guidelines. Moreover, he is the Vice Chair for the American Heart Association (AHA) Advanced Cardiac Life Support (ACLS) guidelines and was the senior author on the national 2015 AHA ACLS guidelines. Dr. Donnino’s has a strong commitment to mentoring the full-range of investigators from pre-medical students to junior faculty and is the recipient of the NIH Mentoring Award (K24). 

Awards and Recognition
Vice Chair of AHA resuscitation guidelines writing group and Vice Chair of ALS ILCOR
 

A full list of Dr. Donnino’s published work can be found on My Bibliography

More information can be found on Dr. Donnino's Harvard Catalyst profile.

 

+Current Projects

  • Neuromuscular blockade for the management of post-cardiac arrest patients.
  • Esmolol to treat cardiovascular effects of septic shock.
  • Neuromuscular Blockade in Post-Cardiac Arrest.
  • Ubiquinol as a metabolic resuscitator in post-cardiac arrest.
  • Oxygen consumption/transport change for early warning detection of shock state.
  • Failure to Rescue in the Intensive Care Unit: A Multi-Disciplinary Approach to Reducing Preventable Cardiac Arrest.
  • Thiamine as a Metabolic Resuscitation in Cardiac Arrest.
  • Ascorbic Acid, Corticosteroids and Thiamine in Septic Shock – ACTS Trial.

+Selected Publications

  • Donnino MW, Andersen LW, Berg KM, Chase M, Sherwin R, Smithline H, Carney E, Ngo L, Patel PV, Liu X, Cutlip D, Zimetbaum P, Cocchi MN; collaborating authors from the Beth Israel Deaconess Medical Center’s Center for Resuscitation Science Research Group. Corticosteroids therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled trial. Crit Care. (2016). 20(1):82. PMID: 27038920; PMC4818959.
  • Donnino MW, Andersen LW, Chase M, Berg K, Tidswell M, Giberson T, Wolfe R, Moskowitz A, Smithline H, Ngo L, Cocchi MN. Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study. Crit Care Med (2016). PMID: 26771781; PMC4754670; NIHMS753328.
  • Andersen LW, Holmberg MJ, Berg KM, Chase M, Cocchi MN, Sulmnte C, Balkema J, MacDonald M, Montissol S, Senthilnathan V, Liu D, Khabbaz K, Lerner A, Novack V, Liu X, Donnino MW. Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial. Crit Care. (2016). 20(1):92. PMID: 27044557; PMC4820988.
  • Donnino MW, Mortensen SJ, Andersen LW, Chase M, Berg KM, Balkema J, Radhakrishnan J, Gazmuri RJ, Liu X, Cocchi MN. Ubiquinol (reduced coenzyme Q10) in patients with severe sepsis or septic shock- a randomized double-blind, placebo-controlled, pilot trial. Crit Care. (2015). 19:275. PMID: 26130237; PMC4520066.
  • Donnino MW, Andersen LW, Berg KM, Reynolds JC, Nolan JP, Morley P, Lang E, Cocchi MN, Xanthos T, Callaway C, Soar J, ALS Task Force. Temperature Management After Cardiac Arrest: An Advisory Statement by the Advanced Life Support (ALS) Task Force of the International Liaison Committee on Resuscitation (ILCOR). Circulation. (2015) 132(25):2448-56 PMID: 26434495
  • Link MS, Berkow LC, Kudenchuk P, Halperin HR, Hess EP, Moitra VK, Neumar R, O’Neil BJ, Paxton JH, Silvers S, White RD, Yannopoulos D, Donnino MW. Part 7: Adult Advanced Cardiovascular Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. (2015) 132(18 Suppl 2):S444-64. PMID: 26472995 Callaway CW, Donnino MW, Flink EL, Geocadin RG, Golan E, Kerber RE, Kern KB, Leary M, Meurer WJ, Peberdy MA, Zimmerman J. Part 8: Post-Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. (2015) 132(18 Suppl 2):S465-82. PMID: 26472996
  • Donnino MW, Salciccioli JD, Howell MD, Cocchi MN, Giberson B, Berg K, Gautam S, Callaway C. Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry. BMJ. (2014) 348:g3028. PMID: 24846323; PMC4027796.
  • Andersen LW, Kurth T, Chase M, Berg KM, Cocchi MN, Callaway C, Donnino MW; American Heart Association’s Get With The Guidelines-Resuscitation Investigators. Early administration of epinephrine (adrenaline) in patients with cardiac arrest with initial shockable rhythm in hospital: propensity score matched analysis. BMJ. (2016). Apr 6;353:i1577. PMID: 27053638; PMC4823528.
  • Andersen LW, Berg KM, Saindon BZ, Massaro JM, Raymond TT, Berg RA, Nadkarni VM, Donnino MW; American Heart Association Get With the Guidelines–Resuscitation Investigators. Time to Epinephrine and Survival After Pediatric In-Hospital Cardiac Arrest. JAMA. (2015). 25;314(8):802-10. PMID: 26305650
  • Andersen LW, Raymond TT, Berg RA, Nadkarni VM, Grossestreuer AV, Kurth T, Donnino MW., for AHA’s Get With The Guidelines-Resuscitation Investigators. Association Between Tracheal Intubation During Pediatric In-Hospital Cardiac Arrest and Survival. JAMA. (2016) Nov 1;316(17):1786-1797. PMID: 27701623.
  • Andersen LW, Granfeldt A, Callaway CW, Bradley SM, Soar J, Nolan JP, Kurth T, Donnino MW. The association between tracheal intubation during adult in-hospital cardiac arrest and survival. JAMA. (2017) Feb 7;317(5):494-506
  • Huang DT, Yealy DM, Filbin MR, Brown AM, Chang CH, Doi Y, Donnino MW, Fine J, Fine MJ, Fischer MA, Holst JM, Hou PC, Kellum JA, Khan F, Kurz MC, Lotfipour S, Lo Vecchio F, Peck-Palmer OM, Pike F, Prunty H, Sherwin RL, Southerland L, Terndrup T, Weissfeld LA, Yabes J, Angus DC. Procalcitonin-guided use of antibiotics for lower respiratory tract. Infection. ProACT Investigators. N Engl J Med.2018 May 20.
  • Donnino MW, Liu X, Andersen LW, Rittenberger JC, Abella BS, Gaieski DF, Ornato JP, Gazmuri RJ, Grossestreuer AV, Cocchi MN, Abbate A, Uber A, Clore J, Peberdy MA, Callaway CW; National Post Arrest Research Consortium (NPARC) Investigators. Characterization of mitochondrial injury after cardiac arrest (COMICA). Resuscitation. 2017 Apr;113:56-62.
  • Ikeda K, Liu X, Kida K, Marutani E, Hirai S, Sakaguchi M, Andersen LW, Bagchi A, Cocchi MN, Berg KM, Ichinose F, Donnino MW. Thiamine as a neuroprotective agent after cardiac arrest. Resuscitation. 2016 Aug 105:138-44.